Analysis of the Characteristics of Microbial Flora in Pharmaceutical Water Systems and Discussion on Their Cultivation
10.13748/j.cnki.issn1007-7693.20223543
- VernacularTitle:制药用水系统微生物菌群特性分析及培养探讨
- Author:
ZHANG Xuhong
1
;
ZHENG Xiaoling
2
,
3
;
GONG Wanzi
4
;
WANG Yinhuan
3
;
LI Jue
2
,
3
;
ZHANG Xinping
5
;
WU Jiequn
1
Author Information
1. Zhejiang University of Technology, Hangzhou 310014, China
2. Zhejiang Institute for Food and Drug Control, Key Laboratory of Drug Contacting Materials Quality Control of Zhejiang Provincial, Hangzhou 310052, China
3. Zhejiang Institute for Food and Drug Control, NMPA Key Laboratory for Testing and Risk Warning of Pharmaceutical Microbiology, Hangzhou 310052, China
4. China Pharmaceutical University, Nanjing 210009, China
5. Zhejiang Jingxin Pharmaceutical Co., Ltd., Shaoxing 312500, China
- Publication Type:Journal Article
- Keywords:
pharmaceutical water;
microbiota;
biofilms;
culture medium
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(18):2608-2616
- CountryChina
- Language:Chinese
-
Abstract:
Pharmaceutical water is the most widely used raw material and solvent in the process of pharmaceutical products, which is widely used in the cleaning and disinfecting process of appliances, equipment, facilities and systems, and is involved in the whole process of pharmaceutical products. Pharmaceutical water is one of the main sources of microbial contamination of pharmaceutical products, so the microbial safety of pharmaceutical water is crucial for pharmaceutical quality. This paper mainly introduces the characterization of the pharmaceutical water system, and conducts biofilm analysis. Due to the characteristics of oligotrophic and slow-growing of microorganisms in the pharmaceutical water system, this paper also further discusses the microbiological testing and culture methods of pharmaceutical water, so as to provide reference for the establishment of a scientific and reasonable microbiological testing system, as well as provide an important theoretical basis and new ideas for further research on hard-to-culture microorganisms.
