Study on Pharmacokinetics and Bioavailability of Naproxen Choline Ionic Liquid in Rat
10.13748/j.cnki.issn1007-7693.20230029
- VernacularTitle:萘普生胆碱离子液体在大鼠体内的药动学及生物利用度研究
- Author:
TANG Yimei
1
,
2
,
3
;
HU Benquan
1
,
2
,
3
;
ZHANG Bo
1
,
2
,
3
;
XIN Nina
1
,
2
,
3
;
HE Maofang
1
,
2
,
3
;
ZHANG Yuzhen
1
,
2
,
3
Author Information
1. College of Pharmaceutical, Xi'
2. an Medical University, Xi'
3. an 710021, China
- Publication Type:Journal Article
- Keywords:
naproxen;
choline ionic liquid;
pharmacokinetics;
bioavailability
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(18):2506-2511
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the pharmacokinetics and bioavailability of naproxen choline ionic liquid in rats after intragastric administration. METHODS Naproxen choline ionic liquid was given to rats by intragastric administration. Blood samples were collected at different time points after administration. The blood samples were precipitated by methanol and then centrifuged, and then an Extend-C18 column(4.6 mm×250 mm, 5 μm) was used. Methanol(A)-0.3% phosphoric acid aqueous solution(B) (74:26) was used as the mobile phase, the flow rate was 0.8 mL·min-1, and the detection wavelength was 230 nm. Indomethacin and naproxen were used as internal standard and tested object in determination of naproxen choline ionic liquid in rat plasma. Pharmacokinetic parameters were calculated using DAS 2.0 software. RESULTS After intragastric administration of naproxen suspension to rats, its t1/2α was 5.12 h, t1/2β was 10.13 h, Tmaxwas 2 h, Cmax was 112.92 mg·L-1, and AUC(0-t) was 1 091.01 mg·L-1·h. After intragastric administration of naproxen choline, its t1/2α was 5.64 h, t1/2β was 69.32 h, Tmax was 1 h, Cmax was 135.97 mg·L-1, AUC(0-t) was 1 305.79 mg·L-1·h, and the relative bioavailability was 119.686%. CONCLUSION After intragastric administration of naproxen choline to rats, the peak concentration and bioavailability of the naproxen in vivo are higher than those of the common suspension, and the peak time is earlier.
