Advances in inflammatory response mechanism and anti-inflammatory treatment with dry eye disease
10.3980/j.issn.1672-5123.2025.3.18
- VernacularTitle:干眼的炎症反应机制及抗炎治疗研究进展
- Author:
Pingping WANG
1
;
Fan JIANG
1
;
Simin LI
1
;
Dongxia YAN
1
;
Juan CHENG
1
Author Information
1. The First Clinical College of Shanxi University of Traditional Chinese Medicine, Jinzhong 030619, Shanxi Province, China
- Publication Type:Journal Article
- Keywords:
dry eye disease;
inflammatory factors;
inflammatory signaling pathways;
anti-inflammation
- From:
International Eye Science
2025;25(3):440-445
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the incidence of dry eye disease(DED)is increasing, positioning it as one of the most prevalent diseases affecting the ocular surface. Inflammatory response is the pathological basis of DED, involving various inflammatory mediators and inflammatory signaling pathways. Consequently, anti-inflammatory treatment emerges as a fundamental strategy for preventing and managing DED. This review summarizes the classic inflammatory factors involved in the development and progression of DED, including interleukins, tumor necrosis factor, matrix metalloproteinases, chemokines, and cell adhesion molecules. It also discusses the relevant inflammatory signaling pathways: the MAPKs pathway, NF-κB pathway, Wnt pathway and TLR pathway. Additionally, this review addresses the mechanisms of action and alterations in relevant biomarkers associated with current first-line recommended anti-inflammatory therapies, including corticosteroids, immunosuppressants, nonsteroidal anti-inflammatory drugs, and traditional Chinese medicine approaches to inflammation management. This comprehensive overview aims to enhance understanding of the inflammatory mechanisms underlying DED while exploring future therapeutic prospects.
