Progress of mesenchymal stem cell-derived extracellular vesicles and combined bioscaffolds in the treatment of corneal alkali burns
10.3980/j.issn.1672-5123.2025.3.12
- VernacularTitle:间充质干细胞来源细胞外囊泡及联合生物支架治疗角膜碱烧伤的研究进展
- Author:
Sataer Aishan ABUDOU
1
;
Xia LI
1
;
Ying ZHOU
1
;
Xiaokang WANG
1
Author Information
1. Department of Ophthalmology, Xinjiang 474 Hospital, Urumqi 830013, Xinjiang Uyghur Autonomous Region, China
- Publication Type:Journal Article
- Keywords:
corneal alkali burns;
mesenchymal stem cells;
extracellular vesicles(EVs);
bioscaffolds
- From:
International Eye Science
2025;25(3):404-409
- CountryChina
- Language:Chinese
-
Abstract:
Corneal alkali burns are a common form of corneal trauma, and their treatment has been a challenge in ophthalmology. Traditional treatments include anti-inflammatory, immunosuppressive, and corneal transplantation, with limited results. This review focuses on the research progress of mesenchymal stem cells(MSCs)and their derived extracellular vesicles(MSCs-EVs)in the treatment of corneal alkali burns. MSCs have the ability of self-renewal, multidirectional differentiation, and immunomodulation, and the MSCs-EVs inherit its function from MSCs. MSCs-EVs inherit the functions of MSCs and has lower immunogenicity and better biocompatibility, which provides a new avenue for ophthalmic treatment. In addition, bioscaffolds are used as scaffolds or drug delivery systems in tissue engineering to promote tissue regeneration due to their excellent biocompatibility and degradability. This article reviews the mechanism of action and research progress of MSCs-EVs and combined bioscaffolds in the treatment of corneal alkali burns, and explores their potential in promoting the repair of corneal alkali burns and improving vision. These findings provide new strategies for the treatment of corneal alkali burns and are expected to improve the prognosis of patients.
