Study on the role of sex hormones and prolactin induced proteins in keratoconus
10.3980/j.issn.1672-5123.2025.3.13
- VernacularTitle:性激素与催乳素诱导蛋白在圆锥角膜中的作用研究
- Author:
Zhaoqian CHEN
1
,
2
;
Wenfang ZHANG
1
,
2
;
Lu GAO
1
,
2
;
Nina ZHANG
1
,
2
;
Jixin LI
1
,
2
Author Information
1. Department of Ophthalmology, the Second Hospital &
2. Clinical Medical School, Lanzhou University, Lanzhou 730000, Gansu Province, China
- Publication Type:Journal Article
- Keywords:
keratoconus;
sex hormone receptor;
female hormone;
androgen;
prolactin inducible protein;
clinical studies
- From:
International Eye Science
2025;25(3):410-415
- CountryChina
- Language:Chinese
-
Abstract:
Keratoconus(KC)is a blinding eye disease caused by a variety of factors, with its pathogenesis still not well understood. In recent years, it has been discovered that sex hormones and prolactin-induced protein(PIP)have a profound impact on the cornea, with more noticeable changes when there are abnormalities in their body content. It has been found that various sex hormone receptors are distributed in the cornea. Based on this, this article reviews a multitude of studies on how sex hormones and PIP affect the cornea, along with relevant clinical research. It has been observed that sex hormones and PIP also play a role in KC patients and influence the occurrence and progression of KC. Additionally, it has been noted that pregnant and lactating women may be more susceptible to KC. Sex hormones and PIP have the potential to become new diagnostic and therapeutic targets. This article not only provides new insights but also offers important references for clinical practice.
