Role of Macrophage Activation and Polarization in Diabetes Mellitus and Its Related Complications and Traditional Chinese Medicine Intervention
10.13422/j.cnki.syfjx.20242398
- VernacularTitle:巨噬细胞激活与极化在糖尿病及其相关并发症的作用及中医药干预
- Author:
Zhichao CHEN
1
;
Qiaoni LIN
1
;
Liya SUN
1
;
Jinxi WANG
1
;
Zishan FU
1
;
Yufeng YANG
1
;
Yan SHI
1
Author Information
1. Liaoning University of Traditional Chinese Medicine，Shenyang 110847，China
- Publication Type:Journal Article
- Keywords:
macrophages;
diabetes mellitus;
traditional Chinese medicine;
insulin resistance
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(6):311-320
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence of diabetes mellitus （DM） is closely related to insulin resistance and islet β cell dysfunction. Modern studies have found that macrophages are widely present in the liver，fat，skeletal muscle，islets， and other tissues and organs. Macrophage M1/M2 polarization plays an important role in the occurrence and development of diabetes mellitus and its related complications by intervening in inflammatory response，improving insulin resistance，and promoting tissue repair. Most of the traditional Chinese medicines that regulate the activation and polarization of macrophages are Qi-replenishing and Yin-nourishing，heat-clearing， and detoxicating medicinal，which are consistent with the etiology and pathogenesis of diabetes and its related complications. Therefore，by summarizing the mechanisms between macrophage activation，polarization， and insulin resistance in various tissues，this paper reviewed traditional Chinese medicine and its effective components and compounds in improving diabetes mellitus and its related complications through multi-channel regulation of macrophage polarization and regulation of M1/M2 ratio，providing references for the future treatment of DM and its related complications with traditional Chinese medicine.
