Traditional Chinese Medicine Treats Acute Lung Injury by Modulating NLRP3 Inflammasome： A Review
10.13422/j.cnki.syfjx.20242002
- VernacularTitle:中药通过调节NLRP3炎症小体治疗急性肺损伤的研究进展
- Author:
Jiaojiao MENG
1
;
Lei LIU
1
;
Yuqi FU
1
;
Hui SUN
1
;
Guangli YAN
1
;
Ling KONG
1
;
Ying HAN
1
;
Xijun WANG
1
Author Information
1. State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine，Chinmedomics Research Center of National Administration of Traditional Chinese Medicine， Heilongjiang University of Chinese Medicine，Harbin 150040，China
- Publication Type:Journal Article
- Keywords:
acute lung injury;
NOD-like receptor protein 3 （NLRP3） inflammasome;
traditional Chinese medicine;
review
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(6):292-301
- CountryChina
- Language:Chinese
-
Abstract:
Acute lung injury （ALI） is one of the most common and critical diseases in clinical practice， with extremely high morbidity and mortality， seriously threatening human life and health. The pathogenesis of ALI is complex， in which the inflammatory response is a key factor. Studies have shown that NOD-like receptor protein 3 （NLRP3） inflammasomes are involved in ALI through mechanisms such as inflammation induction， increased microvascular permeability， recruitment of neutrophils， oxidative stress， and pyroptosis， playing a key role in the occurrence and progression of ALI. Therefore， regulating NLRP3 inflammasomes and inhibiting the release of inflammatory factors can alleviate the damage in ALI. At present， ALI is mainly treated by mechanical ventilation and oxygen therapy， which have problems such as high costs and poor prognosis. In recent years， studies have shown that traditional Chinese medicine （TCM） can reduce the inflammatory response and the occurrence of oxidative stress and pyroptosis by regulating the NLRP3 inflammasome， thus alleviating the damage and decreasing the mortality of ALI. Based on the relevant literature in recent years， this article reviews the research progress in TCM treatment of ALI by regulating NLRP3 inflammasomes， discusses how NLRP3 inflammasomes participate in ALI， and summarizes the active ingredients， extracts， and compound prescriptions of TCM that regulate NLRP3 inflammasomes， aiming to provide new ideas for the clinical treatment of ALI and the development of relevant drugs.
