Application effect of fiberoptic bronchoscopy and alveolar lavage therapy in diagnosis and treatment of recurrent wheezing disorders in children
- VernacularTitle:纤维支气管镜检查及肺泡灌洗治疗在儿童反复喘息性疾病诊治中的应用效果
- Author:
Shuang HONG
1
;
Hongzhi LU
;
Dawei TIAN
;
Haixin YU
;
Zhaochuan YANG
Author Information
- Publication Type:Research Article
- Keywords: fiberoptic bronchoscopy; alveolar lavage therapy; recurrent wheezing diseases in children; serum inflammatory mediators; lung function
- From: Journal of Clinical Medicine in Practice 2024;28(24):44-47
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application effect of fiberoptic bronchoscopy and alveolar lavage therapy in the diagnosis and treatment of recurrent wheezing diseases in children. Methods A total of 151 children with recurrent wheezing diseases were enrolled, and divided into control group (
n =84) and study group (n =67) based on different diagnostic and therapeutic methods. The control group received conventional diagnosis and treatment, while the study group underwent fiberoptic bronchoscopy combined with alveolar lavage therapy. The time to resolution of symptoms and length of hospital stay were compared between the two groups. Additionally, lung function [forced expiratory volume in 1 second (FEV1), FEV1/forced vital capacity (FEV1/FVC) and peak expiratory flow (PEF)], exhaled nitric oxide (FeNO), serum inflammatory mediator levels [C-reactive protein (CRP), procalcitonin (PCT) and white blood cell (WBC) count] and clinical efficacy were compared. Results The absence time of wheezing and pulmonary rales and hospital stay in the study group were significantly shorter than those in the control group (P < 0.05). After treatment, FEV1, FEV1/FVC and PEF in two groups were significantly higher than before treatment, and the study group was significantly higher than the control group (P < 0.05). After treatment, FeNO, CRP, PCT and WBC in two groups were significantly lower than before treatment, and the study group was significantly lower than the control group (P < 0.05). The total effective rate of the study group was 94.03%, which was significantly higher than 77.38% of the control group (P < 0.05). Conclusion Fiberoptic bronchoscopy and alveolar lavage are effective in the diagnosis and treatment of recurrent asthmatic diseases in children, which can effectively relieve symptoms, shorten hospital stay, and improve lung function, FeNO and serum inflammatory mediators.
