Correlation between driver gene mutation and environmental exposure factors in patients with non-small cell lung cancer in Xi'an City
10.3969/j.issn.1006-2483.2025.01.026
- VernacularTitle:西安市非小细胞肺癌患者驱动基因突变与环境暴露因素的相关性分析
- Author:
Yang HU
1
,
2
;
Qianrong WANG
1
,
2
;
Mengxue WANG
1
,
2
;
Na CHENG
1
,
2
;
Meijuan WU
1
,
2
;
Xianna WU
1
,
2
;
Juanhua SUN
1
,
2
Author Information
1. Department of Oncology , The First Affiliated Hospital of the Air Force Medical University , Xi'
2. an , Shaanxi 710032 , China
- Publication Type:Journal Article
- Keywords:
Non-small cell lung cancer;
Drive gene mutation;
Environmental exposure;
Correlation
- From:
Journal of Public Health and Preventive Medicine
2025;36(1):114-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the driver gene mutation status in patients with non-small cell lung cancer (NSCLC) in Xi'an City, and to analyze the association with environmental exposure factors. Methods A total of 305 NSCLC patients admitted to the First Affiliated Hospital of the Air Force Medical University from January 2019 to December 2023 were included. The driver gene mutation status was observed, and the relationship with environmental exposure factors was analyzed. Results The driver gene mutation rate of 305 patients was 46.89%, with EGFR gene mutation accounting for the highest proportion, and 4 cases of gene co-mutations were detected. There was a difference in gender among patients with different single drive gene mutations (P<0.05), and the proportion of EGFR in women was significantly higher (P<0.05). Univariate analysis showed that there were statistical differences in family history, smoking history, long-term cooking history, and fried smoked food intake between patients with driver gene mutation and patients without driver gene mutation (P<0.05). Logistic regression analysis suggested that long-term cooking history (OR=2.392), and fried smoked food intake (OR=2.849) were the environmental exposure factors affecting EGFR gene mutation (P<0.05), and smoking history (OR=1.377) was an environmental exposure factor of KRAS gene mutation (P<0.05). Conclusion EGFR gene mutation accounts for the highest proportion of NSCLC patients in Xi'an City, and is mainly female. Long-term cooking history, and fried smoked food intake are related to EGFR gene mutation. There is a certain association between smoking history and KRAS gene mutation.
