Correlation between IL-6 , chemerin , lipid ratio and insulin resistance in obese patients with type 2 diabetes mellitus
10.3969/j.issn.1006-2483.2025.01.010
- VernacularTitle:肥胖2型糖尿病患者IL-6、chemerin、脂质比值与胰岛素抵抗的相关性分析
- Author:
Yili LUO
1
;
Han CAO
1
;
Lu LIU
2
,
3
;
Lijuan ZHANG
1
Author Information
1. Department of Endocrinology , Songjiang Hospital Affiliated to Shanghai Jiaotong University School of Medicine , Shanghai 201600 , China
2. Department of Endocrinology , Seventh People'
3. s Hospital , Shanghai University of Traditional Chinese Medicine , Shanghai 200120 , China
- Publication Type:Journal Article
- Keywords:
Obesity;
Type 2 diabetes mellitus;
Interleukin-6;
Lipid ratio;
Insulin resistance
- From:
Journal of Public Health and Preventive Medicine
2025;36(1):45-48
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between insulin resistance and interleukin-6 (IL-6), chemerin, total cholesterol (TC)/high density lipoprotein cholesterol (HDL-C) ratio, triglyceride (TG)/HDL-C ratio, low density lipoprotein cholesterol (LDL-C)/HDL-C ratio and insulin resistance in obese patients with type 2 diabetes mellitus (T2DM), and to provide scientific basis for T2DM prevention and control. Methods A total of 355 obese T2DM patients in Songjiang Hospital Affiliated to Shanghai Jiaotong University School of Medicine were selected from January 2021 to December 2023. IL-6, chemerin and lipids were detected, and the assessment of insulin resistance was conducted through the homeostasis model assessment of insulin resistance (HOMA-IR). Results Among the 355 obese T2DM patients, there were 280 cases of insulin resistance, with the incidence rate of 78.87%. The BMI, IL-6, chemerin, TC/HDL-C, LDL-C/HDL-C, and TG/HDL-C in the insulin resistance group were higher than those in the non-insulin resistance group (P<0.05). The above insulin resistant patients were divided into 4 subgroups by means of insulin resistance, and there were significant differences in BMI, IL-6, chemerin, and TG/HDL-C among the subgroups (P<0.05). IL-6, chemerin, and TG/HDL-C were positively correlated with HOMA-IR in obese T2DM patients (P<0.05), while TC/HDL-C and LDL-C/HDL-C had no significant correlation with HOMA-IR (P>0.05). BMI, IL-6, chemerin, and TG/HDL-C were all influencing factors of insulin resistance in obese T2DM patients (P<0.05). Conclusion IL-6, chemerin and TG/HDL-C are correlated with insulin resistance in obese patients with T2DM and are influencing factors for the occurrence of insulin resistance.
