Study on the relationship between hypothalamus extended synaptotagmins and energy balance regulation
10.3969/j.issn.1006-2483.2025.01.001
- VernacularTitle:下丘脑延伸突触结合蛋白和能量平衡调控的关系研究
- Author:
Yunliang GUAN
1
;
Guo ZHANG
2
Author Information
1. College of Basic Medical , PanZhiHua University , PanZhiHua 617099 , China
2. School of Public Health , Tongji Medical College , Huazhong University of Science and Technology , Wuhan , Hubei 430030 , China
- Publication Type:Journal Article
- Keywords:
Energy balance;
Endoplasmic reticulum-plasma membrane junction;
Endoplasmic reticulum stress;
Hypothalamus;
Extended synaptotagmins
- From:
Journal of Public Health and Preventive Medicine
2025;36(1):1-7
- CountryChina
- Language:Chinese
-
Abstract:
Obesity is an important manifestation of the imbalance of energy regulation, and its complications can cause irreparable damage to the body. Finding the pathogenesis of obesity at the molecular level can help fundamentally avoid these irreversible complications. Extended synaptotagmins (E-Syts) are proteins related to the formation of endoplasmic reticulum (ER) and plasma membrane (PM). Because of the short discovery time, there is huge room for exploration. In terms of the role of the established structure of E- Syts at the molecular level, it has a non-negligible link with the pathogenesis of obesity. Starting with the structure of hypothalamus, this paper reviews the literature evidence of this connection, hoping to find a new research angle for reducing the incidence of obesity.
