Association of the adipokine Chemerin with the development and progression of liver fibrosis
- VernacularTitle:脂肪因子Chemerin与肝纤维化发生发展的关系
- Author:
Xinyuan ZHANG
1
;
Nuoqi ZHANG
1
;
Guohui YU
1
;
Wenshuai REN
1
;
Yaling WANG
2
Author Information
- Publication Type:Review
- Keywords: Hepatic Fibrosis; Adipokines; Chemerin
- From: Journal of Clinical Hepatology 2025;41(1):164-169
- CountryChina
- Language:Chinese
- Abstract: Liver fibrosis is the common pathological process in the progression of various chronic liver diseases to liver cirrhosis， and it greatly affects the prognosis of patients with chronic liver diseases. As a novel adipokine， Chemerin participates in the metabolism of glucose and lipids and inflammation， and various studies have shown that the expression level of Chemerin is correlated with the degree of liver fibrosis， suggesting that Chemerin may be involved in the process of liver fibrosis by regulating metabolism and inflammation. Chemerin has shown certain potential in the auxiliary diagnosis of liver fibrosis and the intervention against the progression of liver fibrosis. This article reviews the potential role and mechanism of action of Chemerin in the process of liver fibrosis， in order to provide new ideas for the diagnosis and treatment of liver fibrosis.
