Role of dynamin-related protein 1 in non-alcoholic fatty liver disease
- VernacularTitle:动力蛋白相关蛋白1（Drp1）在非酒精性脂肪性肝病中的作用
- Author:
Haishan SHEN
1
;
Shuo WANG
1
;
Gong FENG
2
Author Information
- Publication Type:Review
- Keywords: Non-alcoholic Fatty Liver Disease; Dyneins; Mitochondria
- From: Journal of Clinical Hepatology 2025;41(1):159-163
- CountryChina
- Language:Chinese
- Abstract: The morphological changes and functions of mitochondria are closely associated with the development and progression of non-alcoholic fatty liver disease （NAFLD）. Dynamin-related protein 1 （Drp1） is one of the primary proteins determining mitochondrial fission， and its activity is strictly controlled to ensure the balance of mitochondrial dynamics according to cellular needs. Drp1 can enhance mitochondrial interactions and mitochondrial fission by promoting the formation of endoplasmic reticulum tubules， and the phosphorylation state and deacetylation of Drp1 can also affect the morphological changes of mitochondria， thereby affecting the status of NAFLD. This article elaborates on the role and mechanism of action of Drp1 in the progression of NAFLD， in order to provide ideas for targeted therapy for NAFLD.
