POEMS syndrome with hepatosplenomegaly as the initial manifestation： A report of two cases
- VernacularTitle:以肝脾肿大为首发表现的POEMS综合征2例报告
- Author:
Ye ZHANG
1
;
Wenqing WANG
2
;
Jing LI
1
;
Qianrong BAI
3
;
Jiayu LI
1
;
Yan CHENG
1
;
Miaomiao FANG
4
;
Nana GAO
5
;
Changxing HUANG
1
Author Information
- Publication Type:Case Reports
- Keywords: POEMS Syndrome; Hepatomegaly; Splenomegaly; Diagnosis
- From: Journal of Clinical Hepatology 2025;41(1):127-132
- CountryChina
- Language:Chinese
- Abstract: POEMS syndrome is a rare condition associated with plasma cell disorders， and it often involves multiple systems and has diverse clinical manifestations. This article reports two cases of POEMS syndrome with hepatosplenomegaly as the initial manifestation. During the course of the disease， the patients presented with lower limb weakness， hepatosplenomegaly， lymph node enlargement， ascites， hypothyroidism， positive M protein， and skin hyperpigmentation， and 18F-FDG PET-CT imaging revealed bone lesions mainly characterized by osteolytic changes and plasma cell tumors. There was an increase in the serum level of vascular endothelial growth factor. The patients were finally diagnosed with POEMS syndrome， and the symptoms were relieved after immunomodulatory treatment.
