Effect of islet macrophages on β-cell function changes during type 2 diabetes mellitus progression based on the "moderate fire generating qi, hyperactive fire consuming qi" theory
10.3969/j.issn.1006-2157.2025.01.003
- VernacularTitle:基于“少火生气，壮火食气”理论探析2型糖尿病进程中胰岛巨噬细胞对β细胞功能变化的影响
- Author:
Yuying ZHANG
1
;
Weiyu HUANG
1
;
Haoyu YUAN
1
;
Baohua WANG
2
;
Saimei LI
2
Author Information
1. The First Clinical Medical College, Guangzhou University of Chinese Medicine
2. The First Affiliated Hospital, Guangzhou University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
type 2 diabetes mellitus;
islet macrophages;
islet β-cells;
moderate fire generating qi;
hyperactive fire consuming qi
- From:
Journal of Beijing University of Traditional Chinese Medicine
2025;48(1):14-20
- CountryChina
- Language:Chinese
-
Abstract:
This study examined the effect of islet macrophages on β-cell function changes during type 2 diabetes mellitus (T2DM) progression based on the traditional Chinese medicine theory that " moderate fire generating qi, hyperactive fire consuming qi" . T2DM is closely associated with chronic low-grade inflammation, with islet macrophages playing a central role in this process. Under physiological conditions, islet macrophages secrete anti-inflammatory and growth factors to regulate the immune response, promote cell proliferation, and support islet β-cell survival and function, reflecting the concept of " moderate fire generating qi" . However, during the pathological process of T2DM, islet macrophages become over-activated and dysfunctional, secreting large amounts of pro-inflammatory factors that trigger severe inflammatory responses and oxidative stress. This process damages islet β-cells, disrupts the islet microenvironment and blood supply, exacerbates local inflammation and structural damage, and worsens the survival environment of β-cells. Ultimately, this leads to fewer β-cells and function loss, aligning with the " hyperactive fire consuming qi" theory, where excessive fire depletes qi and blood. This study enhances the understanding and application of traditional Chinese medicine theories in modern medicine, offering a new perspective on T2DM prevention and treatment. Regulating islet macrophage function and reducing their pro-inflammatory responses may become key strategies for preserving β-cell function and slowing T2DM progression.
- Full text:2025022115312321117Effect of islet macrophages on β-cell function changes during type 2 diabetes mellitus progression based on the _moderate fire generating qi, hyperactive fire consuming qi_ theory.pdf
