Research Progress on the Effects of Silymarin Against Experimental Liver Diseases and Related Clinical Applications
10.13748/j.cnki.issn1007-7693.20222450
- VernacularTitle:水飞蓟素防治实验性肝病的作用及相关临床应用的研究进展
- Author:
ZHANG Juan
1
;
BAI Qingyun
1
;
TIAN Lili
2
Author Information
1. Jiangxi Key Laboratory of Active Ingredients Research of Natural Drug, College of Chemistry and Bioengineering, Yichun University, Yichun 336000, China
2. TCM Dispensary, Pharmacy of Zhejiang Hospital, Hangzhou 310013, China
- Publication Type:Journal Article
- Keywords:
silymarin;
liver disease;
hepatoprotective effect;
mechanism;
clinical application
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(19):2745-2753
- CountryChina
- Language:Chinese
-
Abstract:
Silymarin is a kind of flavonoid compound with various pharmacological effects such as scavenging reactive oxygen species, anti-lipid peroxidation, anti-inflammation and anti-tumor. By reviewing a large number of related literature, found that silymarin has a better preventive and curative effect on various liver diseases. With the deepening of basic research, silymarin can also promote the repair and regeneration of hepatocytes, and when used in combination with antiviral drugs and other hepatoprotective drugs, it can significantly reduce serum aminotransferase levels and improve hepatic fibrosis, and it has the advantages of high safety and good tolerability. In this paper, the preventive and curative effects of silymarin on different liver diseases, its mechanism of action and its clinical application are summarized, with a view to providing reference for in-depth research, drug development and clinical application of silymarin in the prevention and treatment of liver diseases.
