Pharmacoeconomics Evaluation of Utidelone Combined with Capecitabine in the Second-line Treatment of Metastatic Breast Cancer
10.13748/j.cnki.issn1007-7693.20224209
- VernacularTitle:优替德隆联合卡培他滨二线治疗转移性乳腺癌的药物经济学评价
- Author:
ZHANG Sen
1
;
JIA Caifeng
2
;
XU Hao
3
;
LI Sainan
4
;
KANG Shuo
5
Author Information
1. The Fourth Hospital of Hebei Medical University, Department of Pharmacy, Shijiazhuang 050011, China
2. The Fourth Hospital of Hebei Medical University, Department of Clinical Pharmacology, Shijiazhuang 050011, China
3. The Fourth Hospital of Hebei Medical University, Department of Medical Insurance, Shijiazhuang 050011, China
4. The Fourth Hospital of Hebei Medical University, Department of Breast Center, Shijiazhuang 050011, China
5. Department of Medical Insurance, The Second Hospital of Hebei Medical University, Shijiazhuang 050011, China
- Publication Type:Journal Article
- Keywords:
utidelone;
capecitabine;
metastatic breast cancer;
pharmacoeconomics
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(19):2732-2737
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the economics of utidelone combined with capecitabine compared with capecitabine in the second-line treatment of metastatic breast cancer from the perspective of Chinese health-care system. METHODS A partitioned survival model was established using clinical trial data and relevant literature data, with the cycle of 3 weeks and the time horizon of 15 years. Cost and utility data were discounted using a discount rate of 5%. The model output was the incremental cost-effectiveness ratio(ICER), and the willingness-to-pay threshold(WTP) was set to 1-3 times per capita gross domestic product(GDP) in China in 2021(80 976 yuan/QALY-242 928 yuan/QALY). One-way sensitivity analyses and probabilistic sensitivity analyses were performed to evaluate the stability of model results when the model parameters were changed. RESULTS The results of base-case analysis showed that utidelone combined with capecitabine was a high-cost and high-health benefit regimen, and the ICER was 393 949.83 yuan/QALY. One-way sensitivity analyses showed that the price of utidelone was the most influential factor of the ICER, and the probabilistic sensitivity analyses showed that the model results were robustness. CONCLUSION Utidelone combined with capecitabine has no economic advantage compared with capecitabine alone in the second-line treatment of metastatic breast cancer, but in areas with per capita GDP of more than 131 316 yuan, utidelone combined with capecitabine can be considered the cost-effective regimen.
