Prevalence and Risk Factors Associated with Esophagitis in Children with Abdominal Pain.
- Author:
Hyun Jung KWON
1
;
Dae Yong YI
;
Eell RYOO
;
Kang Ho CHO
;
Dong Woo SON
;
Han TCHA
Author Information
1. Department of Pediatrics, Gil Hospital, Gachon University of Medicine and Science, Incheon, Korea. irida@medimail.co.kr
- Publication Type:Original Article
- Keywords:
Esophagitis;
Children;
Abdominal pain
- MeSH:
Abdominal Pain;
Biopsy;
Candidiasis;
Child;
Endoscopy, Gastrointestinal;
Eosinophilic Esophagitis;
Esophagitis;
Esophagitis, Peptic;
Humans;
Physical Examination;
Prevalence;
Risk Factors;
Sensitivity and Specificity;
Stomach;
Vomiting
- From:Korean Journal of Pediatric Gastroenterology and Nutrition
2008;11(2):103-109
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Children with esophagitis express a variety of nonspecific symptoms and signs depending on their age, and diagnosis is limited because gastrointestinal endoscopy (GFS) and biopsy are difficult to perform. The aim of this study was to examine the prevalence of esophagitis in children with upper abdominal pain, to determine the necessity of esophageal biopsy, and to evaluate the associated risk factors. METHODS: We reviewed 266 pediatric patients with upper abdominal pain who underwent history-taking, physical examination, and GFS with esophageal and gastric biopsies between January 2006 and December 2007. Esophagitis was confirmed on biopsy. We analyzed the risk factors for histologic esophagitis and the necessity of esophageal biopsy. RESULTS: The prevalence of esophagitis was 19.9% (53/266 patients). The sensitivity and specificity of endoscopic diagnosis were 41.5% and 77%. Of 53 patients with histologic esophagitis, reflux esophagitis was seen in 50 patients, eosinophilic esophagitis was seen in 2 patients, and esophageal candidiasis was seen in 1 patient. Vomiting was a significant factor in patients under 8 yr of age (p<0.05). H. pylori infection was documented in 41.5% of patients with histologic esophagitis, compared with 58.5% of patients not infected with H. pylori (p<0.05). The possibility of histologic esophagitis was higher in patients with H. pylori infection (OR 2.5, 95% CI 1.2544 to 4.8286) and in those who visited in the spring (OR 2.5, 95% CI 1.2544 to 4.8286). CONCLUSION: We believe esophageal tissue biopsy should be performed in pediatric patients with upper gastrointestinal symptoms who are undergoing GFS and stomach tissue biopsy, especially preschoolers and H. pylori-infected children in the spring.
