Cannabidiol up⁃regulates BDNF and synaptic protein to exert antidepressant effects
10.19405/j.cnki.issn1000-1492.2022.08.006
- Author:
Yan Yang
1
;
Tengteng Ma
1
;
Yujng Bian
1
;
Jiangna Gu
1
;
Yuyuan Sun
1
;
Zhenyong Wen
1
;
Jianping Xie
2
;
Yun Yuan
1
;
Ying Guo
1
Author Information
1. School of Basic Medical Sciences , Kunming Medical University, Kunming 650000
2. Library, Yunnan Minzu University, Kunming 650000
- Publication Type:Journal Article
- Keywords:
cannabidiol;
antidepressant effects;
prefrontal cortex;
hippocampus
- From:
Acta Universitatis Medicinalis Anhui
2022;57(8):1206-1210
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the rapid antidepressant effects of cannabioiol(CBD) on depression-like mice and its possible mechanism.
Methods:Chronic restraint was used to establish a mouse depression model. The test mice were divided into 5 groups: normal control group, model group, positive control group, CBD low-dose group (25 mg/kg) and CBD high-dose group(50 mg/kg). The mice in each group were given intragastric administration one hour before the behavioral experiment. After the behavioral experiment, the hippocampus and prefrontal cortex specimens were collected, and brain-derived neurotrophic factor(BDNF), postsynaptic density protein 95(PSD-95), synaptophysin(SYP) and target of rapamycin(mTOR) were tested by ELISA.
Results:Compared with the model group, the central area activity distance percentage, the central area activity time percentage and total distance increased in the open field experiment in the CBD low-dose group. Compared with the model group, the percentage of immobility in the forced swimming experiment in the low-dose CBD group decreased. The ELISA test results showed that CBD could rapidly increase the concentration of BDNF and PSD-95 in the prefrontal cortex, as well as the concentration of SYP and mTOR in the hippocampus and prefrontal cortex.
Conclusion:CBD can rapidly improve the behavioral performance of depression-like mice, and rapidly up-regulate the level of BDNF and synaptic protein in the hippocampus or prefrontal cortex.
- Full text:2025021915105527521大麻二酚上调BDNF、突触蛋白发挥抗抑郁作用_杨艳.pdf
