Research Progress of Intranasal Drug Delivery System for Treatment of Central Nervous System Diseases
10.13748/j.cnki.issn1007-7693.20232209
- VernacularTitle:鼻腔给药在神经系统疾病治疗中的研究进展
- Author:
YANG Li
1
;
HOU Shuguang
2
;
ZHOU Xuan
3
Author Information
1. Hainan Meikangda Pharmaceutical Co., Ltd., Chengdu 610093, China
2. Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
3. Chengdu Dirui Pharmaceutical Technology Co., Ltd., Chengdu 610093, China
- Publication Type:Journal Article
- Keywords:
intranasal administration;
central nerve system;
blood brain barrier;
drug delivery system
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(20):2865-2871
- CountryChina
- Language:Chinese
-
Abstract:
Intranasal drug administration can avoid the blood-brain barrier, gastrointestinal degradation and liver first-pass effect, and may directly deliver drugs to the brain through the olfactory nerve pathway, so it is being used for the treatment of various neurological diseases. This article reviewed the research progress of intranasal drug delivery in terms of nasal anatomy, transport pathways of intranasal drug delivery for central nervous system diseases, mechanisms of action, clinical application, challenges and novel technologies.
