Effect of Suspending Agent Concentration on Spray Characteristics of Fluticasone Furoate Nasal Spray
10.13748/j.cnki.issn1007-7693.20231892
- VernacularTitle:助悬剂用量对糠酸氟替卡松鼻喷剂喷雾特性的影响
- Author:
LYU Hang
1
;
CHEN Lan
2
;
SHAO Qi
3
Author Information
1. School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China;
2. School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China;Hangzhou Chance Pharmaceuticals Co., Ltd., Hangzhou 311121, China;
3. SPH Sine Pharmaceutical Lab. Co., Ltd., Shanghai 201206, China
- Publication Type:Journal Article
- Keywords:
nasal spray;
Avicel;
actuation parameter;
spray pattern;
plume geometry;
droplet size distribution
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(20):2818-2826
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the effect of the concentration of the suspending aid Avicel® in a suspension nasal spray on the spray pattern, plume geometry and droplet size of nasal spray. METHODS Preparation of Fluticasone furoate nasal suspension with different concentration of Avicel®. Through SprayVIEW® spray test system to test the spray characteristic parameters of nasal spray, and Box-Behnken response surface method was used to analyze the influence of Avicel® concentration on the spray characteristics of nasal spray in vitro. At the same time, the influence of Avicel® concentration on the distribution of spray droplet size and the change of droplet size at different detection distances were investigated. RESULTS Increasing the concentration of the Avicel® would significantly reduce the spray area, spray angle and width(P<0.001), while increasing D50 and overall particle size. It was also found that increasing the actuation velocity would significantly increase the spray area, spray angle and width(P<0.05), and the influence of actuation acceleration on spray characteristics was far less than that of Avicel® concentration and actuation velocity. As the detection distance increased, the droplet size distribution become more concentrated and the span of droplet size distribution become smaller. CONCLUSION In this study, Box-Behnken response surface method is used to observe the antagonistic effects of Avicel® concentration and actuation velocity on spray characteristics, which provides a reference for the selection of Avicel® concentration for nasal sprays as well as the recommended actuation parameters for the device.
