Effect of Suspending Agent Concentration on Spray Characteristics of Fluticasone Furoate Nasal Spray
10.13748/j.cnki.issn1007-7693.20231892
- VernacularTitle:助悬剂用量对糠酸氟替卡松鼻喷剂喷雾特性的影响
- Author:
LYU Hang
1
;
CHEN Lan
1
,
2
;
SHAO Qi
3
Author Information
1. School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
2. Hangzhou Chance Pharmaceuticals Co., Ltd., Hangzhou 311121, China
3. SPH Sine Pharmaceutical Lab. Co., Ltd., Shanghai 201206, China
- Publication Type:Journal Article
- Keywords:
nasal spray;
Avicel;
actuation parameter;
spray pattern;
plume geometry;
droplet size distribution
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(20):2818-2826
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the effect of the concentration of the suspending aid Avicel® in a suspension nasal spray on the spray pattern, plume geometry and droplet size of nasal spray. METHODS Preparation of Fluticasone furoate nasal suspension with different concentration of Avicel®. Through SprayVIEW® spray test system to test the spray characteristic parameters of nasal spray, and Box-Behnken response surface method was used to analyze the influence of Avicel® concentration on the spray characteristics of nasal spray in vitro. At the same time, the influence of Avicel® concentration on the distribution of spray droplet size and the change of droplet size at different detection distances were investigated. RESULTS Increasing the concentration of the Avicel® would significantly reduce the spray area, spray angle and width(P<0.001), while increasing D50 and overall particle size. It was also found that increasing the actuation velocity would significantly increase the spray area, spray angle and width(P<0.05), and the influence of actuation acceleration on spray characteristics was far less than that of Avicel® concentration and actuation velocity. As the detection distance increased, the droplet size distribution become more concentrated and the span of droplet size distribution become smaller. CONCLUSION In this study, Box-Behnken response surface method is used to observe the antagonistic effects of Avicel® concentration and actuation velocity on spray characteristics, which provides a reference for the selection of Avicel® concentration for nasal sprays as well as the recommended actuation parameters for the device.
