Antivirus activity of Zedoary Turmeric Oil Injection against SARS-CoV-2 in vitro and in vivo
10.19405/j.cnki.issn1000-1492.2022.04.030
- Author:
Yuanyuan Zhou
1
;
Zhijuan Dai
2
;
Shujun Zhang
2
;
Yuechun Li
2
;
Yuanrong Dai
3
;
He Wang
4
;
Hailin Wu
5
;
Mengqing Feng
6
;
Xiaokun Li
7
;
Xiaohui Huang
1
;
Guanghui Zhu
2
Author Information
1. School of Pharmacy，Anhui Medical University，Hefei 230032
2. Dept of Pharmacy，The Second Affiliated Hospital of Wenzhou Medical University，Wenzhou 325035
3. Dept of Respiratory Medicine，The Second Affiliated Hospital of Wenzhou Medical University，Wenzhou 325035
4. School of Chinese Materia Medica，Shanghai University of Chinese Medicine ，Shanghai 201203
5. Hefei Future Drug Development Co．LTD，Hefei 242811
6. Hefei Zhongkupresen Biomedical Technology Co．LTD，Hefei 242811
7. School of Pharmacy，Wenzhou Medical University，Wenzhou 325035
- Publication Type:Journal Article
- Keywords:
Zedoary Turmeric Oil Injection;
SARS-CoV-2 virus;
antiviral activity
- From:
Acta Universitatis Medicinalis Anhui
2022;57(4):664-667，672
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:To study the antiviral effect ofZedoary TurmericOil Injection on novel coronavirus, SARS-CoV-2 viroid cell lines were preparedin vitroand treated with different concentrations of Zedoary Oil. The cell number and relative fluorescence value(RLU) were observed and measured, and the 50% effective inhibitory concentration(IC 50) was calculated. Four patients with Coronavirus Disease 2019 were clinically included, including 2 in the control group and 2 in the experimental group. The control group received conventional treatment, and the experimental group receivedZedoary TurmericOil Injection in addition to conventional treatment. The nucleic acid conversion rate, conversion time, pulmonary imaging changes, fever reduction time, clinical improvement time and adverse events of the patients were observed.In vitroexperiment, the relative fluorescence value decreased with increasing concentration ofZedoary TurmericOil, which was significantly different from that of the control group(P<0.05). The IC50 was 0.26 μg/ml.In vivostudy, the novel coronavirus nucleic acid in stool of case 1 in the test group turned negative in 3 days, the cough symptom of case 2 was significantly relieved, and there was obvious absorption in pulmonary imaging. The negative conversion time of novel coronavirus nucleic acid in the control group was 5 and 7 days respectively. No adverse events occurred in the experimental group.Zedoary TurmericOil had strong inhibitory effect on SARS-COV-2 virusin vitrowhich was dose-dependent.In vivotreatment of COVID-19,Zedoary TurmericOil Injection combined with conventional treatment can improve the cough caused by SARS-COV-2 infection, promote SARS-COV-2 to turn negative, promote absorption of lung lesions, and reduce lung injury, with no obvious adverse events.
- Full text:2025021908453149836莪术油注射液抗新型冠状病毒作用的体内外研究_周园园.pdf
