Expression of miR-155 in peripheral blood of type 2 diabetes patients associated with diabetic foot ulcer and its clinical significance
- Author:
Tianqi Zhao
1
;
Xiaotong Zhao
1
;
Murong Xu
1
;
Yin Tang
1
;
Zeguo Jia
1
;
Li Luo
1
;
Songtao Tang
1
;
Qiu Zhang
1
;
Mingwei Chen
1
Author Information
- Publication Type:Journal Article
- Keywords: type 2 diabetes mellitus; diabetic foot ulcer; microRNA-155; risk factor
- From: Acta Universitatis Medicinalis Anhui 2022;57(4):659-663
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of miR-155 in peripheral blood of type 2 diabetes patients(T2 DM) associated with diabetic foot ulcer(DFU) and its relationship with the onset of DFU.
Methods:Sixty newly diagnosed T2 DM patients without DFU(T2 DM group), 112 T2 DM patients with DFU(DFU group), and 60 healthy controls with normal glucose tolerance(NC group) were included. MiR-155 levels were determined by quantitative real-time PCR, while clinical features and risk factors of DFU were explored.
Results:A significant decrease in the expression level of miR-155 in peripheral blood was observed in T2 DM group compared with NC group(P<0.05), and a markedly increased miR-155 expression level was noted in DFU group compared with T2 DM group(P<0.01). Moreover, there was a positive correlation between the expression level of miR-155 in peripheral blood and the course of foot ulcer and Wagner grade of foot ulcer(P=0.02,P=0.01) while a negative correlation in the expression level of miR-155 with healing rate of DFU after eight weeks(P=0.04). The multiple stepwise logistic regression analysis confirmed that a high expression of miR-155 was an independent risk factor for DFU(OR=3.98,P=0.002).
Conclusion: An increased expression of miR-155 in peripheral blood of T2 DM patients is an independent risk factor for DFU and is closely related to the prognosis of DFU. - Full text:20250219083523599562型糖尿病足溃疡患者外周血...表达水平的改变及其临床意义_赵天琦.pdf
