Association analysis between SNPs in VGLL4 and risk of non-cardia gastric cancer
10.19405/j.cnki.issn1000-1492.2022.04.024
- Author:
Xia Yang
1
;
Wenjie Dong
1
;
Fang Gao
2
;
Jinbao Wu
3
;
Licong Ma
3
;
Tong Dang
3
;
Xianmei Meng
3
;
Yanbin Jia
4
Author Information
1. School of Basic Medicine and Forensic Medicine，Baotou Medical College，Baotou 014060
2. School of Medical Technology and Anesthesiology，Baotou Medical College，Baotou 014060
3. Inner Mongolia Institute of Digestive Diseases， The Second Affiliated Hospital of Baotou Medical College，Baotou 014030
4. School of Basic Medicine and Forensic Medicine，Baotou Medical College，Baotou 014060；Inner Mongolia Institute of Digestive Diseases， The Second Affiliated Hospital of Baotou Medical College，Baotou 014030；School of Nursing，Baotou Medical College，Baotou 014060
- Publication Type:Journal Article
- Keywords:
vestigial like family member 4;
single nucleotide polymorphism;
non-cardia gastric cancer;
genetic sus- ceptibility
- From:
Acta Universitatis Medicinalis Anhui
2022;57(4):636-639
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the associations of the single nucleotide polymorphism(SNP) rs1803489, rs7617620 and rs13078528 in vestigial like family member 4(VGLL4) gene with the risk of non-cardia gastric cancer.
Methods:The case-control study design was used. 450 cases with non-cardia gastric cancer confirmed by pathology and 450 normal controls were collected in the Han population in Baotou; SNP rs1803489, rs7617620, and rs13078528 inVGLL4were genotyped using polymerase chain reaction(PCR)-restriction fragment length polymorphism(RFLP) technology.
Results:VGLL4gene SNP rs1803489 was associated with the risk of non-cardia gastric cancer in the Han population in Baotou. Compared with the carriers of GG genotype, the carriers of AG genotype had a higher risk of non-cardia gastric cancer(OR=1.511, 95%CI=1.095-2.085,P<0.05). SNP rs7617620 and rs13078528 were not associated with non-cardia gastric cancer(P>0.05).
Conclusion:SNP rs1803489 inVGLL4may have an effect on the risk of non-cardia gastric cancer in the Han population in Baotou. SNP rs7617620 and rs13078528 may not play a major role in the risk of non-cardia gastric cancer.
- Full text:2025021815433365331VGLL4基因多态性与非贲门胃癌遗传易感性的关系_杨霞.pdf
