Analysis of the mechanism of curcumol in regulating iron death and autophagy based on systemic pharmacology
- Author:
Jiahui Wang
1
;
Wenxing He
1
;
Rujun Huang
1
;
Jiaxi He
1
;
Xiaoqing Li
1
;
Yang Zheng
1
;
Lei Wang
1
Author Information
- Publication Type:Journal Article
- Keywords: curcumol; systemic pharmacology; ferroptosis; autophagy
- From: Acta Universitatis Medicinalis Anhui 2022;57(4):621-625
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the molecular biological mechanism of curcumol in regulating ferroptosis and autophagy.
Methods:The Pharm Mapper database was used to screen out curcumol targets, various known related databases were used to establish a database of ferroptosis and autophagy related targets, and the String database was used to construct a protein-protein interaction network. The key targets were enriched and analyzed using DAVID database.
Results:152 curcumol targets, 259 ferroptosis targets, and 796 autophagy targets were obtained; curcumol mainly regulated the ferroptosis process through PTGS2, ALB, MAPK1, MAPK8, and MAPK14 targets, and curcumol mainly through HSP90 AA1, MAPK1, MAPK8, ALB, NOS3 targets regulated the autophagy process, and curcumol mainly regulated the ferroptosis and autophagy process through ALB, MAPK1, MAPK8 targets.
Conclusion:Curcumol can exert pharmacological effects by regulating ferroptosis and autophagy. - Full text:2025021815260983351基于系统药理学探讨莪术醇调...铁死亡和细胞自噬的作用机制_王佳慧.pdf
