Antidepressant effects of extracts from Zanthoxylum bungeanum and Zanthoxylum schinifolium in mice exposed to chronic restraint stress
10.19405/j.cnki.issn1000-1492.2022.04.016
- Author:
Bangyin Tan
1
,
2
,
3
;
Haofei Yu
4
;
Suting Zhang
5
;
Jing Wang
5
;
Wenyao Yin
5
;
Caifeng Ding
4
;
Rongping Zhang
4
;
Ying Guo
5
;
Lanchun Zhang
4
;
Jianping Xie
6
Author Information
1. School of Basic Medical Sciences，Kunming Medical University，Kunming 650500
2. 2 School of Pharmaceutical Science ＆ Yunnan Key Laboratory of Pharmacology for Natural Products，Dept of Laboratory Animal，Kunming Medical University，Kunming 650500School of Basic Medical Sciences，Kunming Medical University，Kunming 650500
3. School of Pharmaceutical Science ＆ Yunnan Key Laboratory of Pharmacology for Natural Products，Dept of Laboratory Animal，Kunming Medical University，Kunming 650500
4. School of Pharmaceutical Science ＆ Yunnan Key Laboratory of Pharmacology for Natural Products，Dept of Laboratory Animal，Kunming Medical University，Kunming 650500
5. School of Basic Medical Sciences，Kunming Medical University，Kunming 650500
6. Library of Yunnan Minzu University，Kunming 650500
- Publication Type:Journal Article
- Keywords:
Zanthoxylum bungeanum;
Zanthoxylum schinifolium;
depression;
chronic restraint stress
- From:
Acta Universitatis Medicinalis Anhui
2022;57(4):593-598
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the antidepressant effects of extracts fromZanthoxylum bungeanumandZanthoxylum schinifoliumin mice exposed in chronic restraint stress.
Methods:45 mice of SPF male ICR were randomly divided into five groups: normal group, model group, sertraline hydrochloride group,Zanthoxylum bungeanumextract group andZanthoxylum schinifoliumextract group, with 9 mice in each group. Except for the normal group, mice in all groups were chronically restrained to establish the depressive model. The normal group and model group were given olive oil by intragastric administration, and other groups were given sertraline hydrochloride(10 mg/kg),Zanthoxylum bungeanumextract(200 mg/kg) andZanthoxylum schinifoliumextract(200 mg/kg), respectively. The behaviors of mice in each group were evaluated by open-field test and forced swimming test. The levels of brain-derived neurotrophic factor(BDNF), 5-hydroxytryptophan(5-HT), glutathione(GSH) and nitric oxide(NO) in serum and brain were determined by ELISA.
Results:Compared with model group,Zanthoxylum bungeanumextract could reduce the percentage of immobility time in forced swimming test, increase the level of cortical BDNF, and improve the levels of 5-HT and GSH in cortex and serum, with statistical significance(P<0.05).Zanthoxylum schinifoliumextract could improve the behavior of mice in open field test and forced swimming test, increase the levels of cortex 5-HT and serum GSH, and decrease the contents of NO in serum and cortex.
Conclusion:The extracts ofZanthoxylum bungeanumandZanthoxylum schinifoliumcan improve the depression-like behaviors of mice exposed to chronic restraint stress.
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