The role of circulating inflammatory cytokines in cardiopulmonary bypass-related organs injuries and the treatments
- VernacularTitle:循环炎性因子在体外循环相关器官损伤中的作用及相关治疗
- Author:
Jinghan ZHANG
1
;
Lei DU
2
;
Daming GOU
3
Author Information
1. Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, Guizhou, P. R. China
2. Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China
3. Department of Anesthesiology, Kweichow Moutai Hospital, Zunyi, 564512, Guizhou, P. R. China
- Publication Type:Journal Article
- Keywords:
The role of circulating inflammatory cytokines in cardiopulmonary bypass-related organs injuries and the treatments
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2025;32(01):129-135
- CountryChina
- Language:Chinese
-
Abstract:
Systemic inflammatory response (SIR) evoked by cardiopulmonary bypass (CPB) is still one of the major causes of postoperative multiple organs injuries. Since the concentrations of circulating inflammatory factors are positively associated with postoperative adverse events, removal or inhibition of inflammatory factors are considered as effective treatments to improve outcomes. After more than 20 years of research, however, the results are disappointed as neither neutralization nor removal of circulating inflammatory factors could reduce adverse events. Therefore, the role of circulating inflammatory factors in CPB-related organs injuries should be reconsidered in order to find effective therapies. Here we reviewed the association between circulating inflammatory factors and the outcomes, as well as the current therapies, including antibody and hemadsorption. Most importantly, the role of circulating inflammatory factors in SIR was reviewed, which may be helpful to develop new measures to prevent and treat CPB-related organs injuries.
