Factors affecting drug-induced liver injury: antithyroid drugs as instances.
10.3350/cmh.2014.20.3.237
- Author:
Reza HEIDARI
1
;
Hossein NIKNAHAD
;
Akram JAMSHIDZADEH
;
Narges ABDOLI
Author Information
1. Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. rezaheidari@hotmail.com
- Publication Type:Review
- Keywords:
Drug induced liver injury (DILI);
Endocrinology;
Hepatotoxicity;
Idiosyncratic hepatic injury;
Risk factors
- MeSH:
Animals;
Antithyroid Agents/*adverse effects/chemistry/therapeutic use;
Disease Models, Animal;
Drug-Induced Liver Injury/drug therapy/*etiology;
Graves Disease/drug therapy;
Humans;
Hyperthyroidism/drug therapy;
Protective Agents/therapeutic use;
Reactive Oxygen Species/metabolism;
Risk Factors
- From:Clinical and Molecular Hepatology
2014;20(3):237-248
- CountryRepublic of Korea
- Language:English
-
Abstract:
Methimazole and propylthiouracil have been used in the management of hyperthyroidism for more than half a century. However, hepatotoxicity is one of the most deleterious side effects associated with these medications. The mechanism(s) of hepatic injury induced by antithyroid agents is not fully recognized yet. Furthermore, there are no specific tools for predicting the occurrence of hepatotoxicity induced by these drugs. The purpose of this article is to give an overview on possible susceptibility factors in liver injury induced by antithyroid agents. Age, gender, metabolism characteristics, alcohol consumption, underlying diseases, immunologic mechanisms, and drug interactions are involved in enhancing antithyroid drugs-induced hepatic damage. An outline on the clinically used treatments for antithyroid drugs-induced hepatotoxicity and the potential therapeutic strategies found to be effective against this complication are also discussed.
