Cell-to-cell communications of cGAS-STING pathway in tumor immune microenvironment
10.3724/zdxbyxb-2023-0482
- VernacularTitle:肿瘤免疫微环境中cGAS-STING信号通路的细胞间信号传递
- Author:
Mengqiu WANG
1
;
Pinglong XU
;
Qirou WU
Author Information
1. 浙江大学生命科学研究院,浙江 杭州 310058
- Keywords:
Tumor microenvironment;
cGAS-STING;
Cell-to-cell communication;
Double stranded DNA;
Tumor immunity;
Immune responses;
Review
- From:
Journal of Zhejiang University. Medical sciences
2024;53(1):15-24
- CountryChina
- Language:Chinese
-
Abstract:
Targeting cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)-stimulator of interferon genes(STING)pathway is a promising strategy for tumor treatment.The pattern recognition receptor cGAS identifies dsDNA and catalyzes the formation of a second messenger 2′3′-cyclic guanosine monophosphate-adenosine monophosphate(cGAMP),activating the downstream interferons and pro-inflammatory cytokines through the adaptor protein STING.Notably,in tumor immune microenvironment,key components of cGAS-STING pathway are transferred among neighboring cells.The intercellular transmission under these contexts serves to sustain and amplify innate immune responses while facilitating the emergence of adaptive immunity.The membrane-based system,including extracellular vesicles transport,phagocytosis and membrane fusion transmit dsDNA,cGAMP and activated STING,enhances the immune surveillance and inflammatory responses.The membrane proteins,including a specific protein channel and intercellular gap junctions,transfer cGAMP and dsDNA,which are crucial to regulate immune responses.The ligand-receptor interactions for interferon transmission amplifies the anti-tumor response.This review elaborates on the regulatory mechanisms of cell-to-cell communications of cGAS-STING pathway in tumor immune microenvironment,explores how these mechanisms modulate immunological processes and discusses potential interventions and immunotherapeutic strategies targeting these signaling cascades.
