Chemotherapy induced liver abnormalities: an imaging perspective.
10.3350/cmh.2014.20.3.317
- Author:
Ankush SHARMA
1
;
Roozbeh HOUSHYAR
;
Priya BHOSALE
;
Joon Il CHOI
;
Rajesh GULATI
;
Chandana LALL
Author Information
1. Department of Internal Medicine, University of California, Irvine, Orange, CA, USA. ankushs@hs.uci.edu
- Publication Type:Case Report
- Keywords:
Chemotherapy;
Hepatic toxicity;
Pseudocirrhosis;
Steatosis;
Hepatic Necrosis;
Hepatitis
- MeSH:
Adult;
Aged;
Antibiotics, Antineoplastic/adverse effects/therapeutic use;
Antimetabolites, Antineoplastic/adverse effects/therapeutic use;
Antineoplastic Agents/*adverse effects/therapeutic use;
Antineoplastic Agents, Alkylating/adverse effects/therapeutic use;
Drug-Induced Liver Injury/etiology/radiography;
Enzyme Inhibitors/adverse effects/therapeutic use;
Fatty Liver/etiology/radiography;
Female;
Humans;
Immunotherapy;
Liver Cirrhosis/etiology/radiography;
Liver Diseases/etiology/*radiography;
Male;
Middle Aged;
Neoplasms/therapy;
Tomography, X-Ray Computed
- From:Clinical and Molecular Hepatology
2014;20(3):317-326
- CountryRepublic of Korea
- Language:English
-
Abstract:
Treating patients undergoing chemotherapy who display findings of liver toxicity, requires a solid understanding of these medications. It is important for any clinician to have an index of suspicion for liver toxicity and be able to recognize it, even on imaging. Cancer chemotherapy has evolved, and newer medications that target cell biology have a different pattern of liver toxicity and may differ from the more traditional cytotoxic agents. There are several hepatic conditions that can result and keen clinical as well as radiographic recognition are paramount. Conditions such as sinusoidal obstructive syndrome, steatosis, and pseudocirrhosis are more commonly associated with chemotherapy. These conditions can display clinical signs of acute hepatitis, liver cirrhosis, and even liver failure. It is important to anticipate and recognize these adverse reactions and thus appropriate clinical action can be taken. Often times, patients with these liver manifestations can be managed with supportive therapies, and liver toxicity may resolve after discontinuation of chemotherapy.
