Effect of radix scutellariae microemulsion gel on chronic eczema in mice model
10.12092/j.issn.1009-2501.2024.04.013
- VernacularTitle:黄芩微乳凝胶对小鼠慢性湿疹的疗效研究
- Author:
Ke WANG
1
;
Chenbing NIU
;
Yinxia CHANG
;
Xuemei QIN
;
Zhihua LUAN
;
Yue ZHANG
Author Information
1. 山西中医药大学,中药与食品工程学院,太原 030619,山西
- Keywords:
baicalein;
wogonin;
microemulsion;
microemulsion gel;
transdermal;
eczema
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(4):447-454
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To prepare radix scutellariae mi-croemulsion gel and investigate its therapeutic ef-fect on chronic eczema based on the previous re-search of radix scutellariae self microemulsion.METHODS:The gel matrix and humectant were op-timized by single factor method and response sur-face method to obtain the formula and preparation technique of the gel.The Franz diffusion cell meth-od was used to evaluate the transdermal proper-ties of microemulsion and microemulsion gel in vi-tro.By establishing a chronic eczema model in the mouse ear,the swelling degree,swelling inhibition rate,pathological changes and tumor necrosis fac-tor a(TNF-a),Interleukin-1β(IL-1β)and interleukin-6(IL-6)of radix scutellariae microemulsion gel were measured,to investigate the therapeutic ef-fect on chronic eczema in mice.RESULTS:The physi-cal and chemical properties of radix scutellariae mi-croemulsion gel were stable.Compared with micro-emulsion,the microemulsion gel had better trans-dermal performance.The cumulative transdermal amount of baicalein and wogonin,the main compo-nents of microemulsion gel,was 1.85 times and 2.77 times of that of microemulsion respectively.Moreover,the steady flow rate and permeability co-efficient of microemulsion gel significantly in-creased,and the lag time significantly shortened.Pharmacodynamic study showed that compared with the model group,the radix scutellariae micro-emulsion gel could significantly reduce the ear swelling of mice(P＜0.05),and the serum inflamma-tory factor TNF-a,IL-1β and IL-6 reduced content by over 37％.Compared with the radix scutellaria aqueous extract and aqueous extract gel,the treat-ment of chronic eczema was better.CONCLUSION:The preparation process of radix scutellaria micro-emulsion gel is feasible,with strong transdermal property,and a significant therapeutic effect on chronic eczema.
