Near-tetraploidy Acute Myeloid Leukemia with RUNX1-RUNX1T1 Rearrangement Due to Cryptic t(8;21).
10.3343/kjlm.2009.29.6.510
- Author:
Mijeong IM
1
;
Jin Kyung LEE
;
Dong Young LEE
;
Young Joon HONG
;
Seok Il HONG
;
Hye Jin KANG
;
Yoon Hwan CHANG
Author Information
1. Department of Laboratory Medicine, Korea Cancer Center Hospital, Seoul, Korea. cyhlabo@kcch.re.kr
- Publication Type:Case Report ; English Abstract
- Keywords:
Tetraploidy;
Near-tetraploidy;
AML;
RUNX1-RUNX1T1;
Cryptic t(8;
21)
- MeSH:
Adult;
Chromosomes, Human, Pair 21;
Chromosomes, Human, Pair 8;
Core Binding Factor Alpha 2 Subunit/*genetics;
Female;
Gene Rearrangement;
Humans;
In Situ Hybridization, Fluorescence;
Karyotyping;
Leukemia, Myeloid, Acute/*genetics;
*Polyploidy;
Proto-Oncogene Proteins/*genetics;
Transcription Factors/*genetics;
Translocation, Genetic
- From:The Korean Journal of Laboratory Medicine
2009;29(6):510-514
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Tetraploidy or near-tetraploidy is a rare cytogenetic abnormality found in AML, and is divided into primary and secondary forms. The secondary tetraploidy or near-tetraploidy found in AML is known to be specifically associated with t(8;21). In this case report, FISH analysis detected RUNX1-RUNX1T1 gene rearrangement in the absence of cytogenetic abnormality of t(8;21), which suggests the presence of unvailed t(8;21). This is the first case report of tetraploidy or near-tetraploidy AML with cryptic RUNX1/RUNX1T1 in Korea. Although the prognosis of tetraploidy or near- tetraploidy with t(8;21) is known to be poor, this patient shows a relatively good clinical course compared to other reported cases.
