A Case of Multiple Bowen's Disease Improved with Isotretinoin and Interferon Alpha-2a.
- Author:
Jeong Soo KIM
1
;
Hyeon Woong KIM
;
Ki Beom SUHR
;
Jeung Hoon LEE
;
Jang Kyu PARK
Author Information
1. Department of Dermatology, College of Medicine Chungnam National University, Taejon, Korea. seokb@cnu.ac.kr
- Publication Type:Case Report
- Keywords:
Multiple Bowen's disease;
Isotretinoin;
Interferon alpha
- MeSH:
Adult;
Bowen's Disease*;
Epidermis;
Female;
Humans;
Interferon-alpha;
Interferons*;
Isotretinoin*;
Lower Extremity;
Parakeratosis;
Skin
- From:Korean Journal of Dermatology
2002;40(5):592-595
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of multiple Bowen's disease in a 36-year-old female patient who had multiple erythematous, scaly patches and plaques distributed diffusely on her trunk, upper and lower extremities. Histopathologic studies showed hyperkeratosis, parakeratosis, acanthosis, and thickening of the rete ridges in the epidermis. The cellular architecture is disorganized, and individually keratinizing cells and atypical cells were seen at all levels of the epidermis. The skin lesions were improved with treatment with oral isotretinoin, 0.5mg/kg per day in combination with interferon alpha-2a administrated subcutaneously at 3 million units once a week.
