How to Correctly Understand and Use the Low-quality Evidence to Formulate Recommendations in Guidelines

Qianling SHI; Hui LIU; Zijun WANG; Xufei LUO; Bingyi WANG; Nan YANG; Wenbo MENG; Yaolong CHEN

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How to Correctly Understand and Use the Low-quality Evidence to Formulate Recommendations in Guidelines

VernacularTitle:正确理解和应用低质量证据形成指南推荐意见
Author: Qianling SHI ¹ ; Hui LIU ² ; Zijun WANG ² ; Xufei LUO ² ; Bingyi WANG ² ; Nan YANG ² ; Wenbo MENG ³ ; Yaolong CHEN ⁴
Author Information

1. The First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, China;Research Unit of Evidence-based Evaluation and Guidelines, Chinese Academy of Medical Sciences, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China;Key Laboratory of Evidence-based Medicine of Gansu Province, Lanzhou 730000, China;Institute of Health Data Science, Lanzhou University, Lanzhou 730000, China;
2. Research Unit of Evidence-based Evaluation and Guidelines, Chinese Academy of Medical Sciences, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China;Key Laboratory of Evidence-based Medicine of Gansu Province, Lanzhou 730000, China;Institute of Health Data Science, Lanzhou University, Lanzhou 730000, China;Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China;
3. Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, China;
4. Research Unit of Evidence-based Evaluation and Guidelines, Chinese Academy of Medical Sciences, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China;Key Laboratory of Evidence-based Medicine of Gansu Province, Lanzhou 730000, China;Institute of Health Data Science, Lanzhou University, Lanzhou 730000, China;Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China;Guidelines and Standards Research Center, Chinese Medical Association Publishing House, Lanzhou 730000, China;WHO Collaborating Center for Guideline Implementation and Knowledge Translation, Lanzhou 730000, China;
Publication Type:Journal Article
Keywords: clinical practice guidelines; recommendations; quality of evidence; GRADE
From: Medical Journal of Peking Union Medical College Hospital 2024;15(3):676-685
CountryChina
Language:Chinese
Abstract:
The essence of clinical practice guidelines lies in their recommendations. It is common to find strong recommendations supported by low-quality evidence in current published guidelines. There is a typical misunderstanding among medical professionals that without high-quality evidence, it is impossible to develop high-quality guidelines or only expert consensus can be developed. Based on the GRADE approach, this paper explains the concept and clinical significance of low-quality evidence, and introduces the methods for formulating recommendations based on low-quality evidence in guidelines, with the aim to provide reference for guideline developers and users in China.