Dietary germanium biotite supplementation enhances the induction of antibody responses to foot-and-mouth disease virus vaccine in pigs.
10.4142/jvs.2014.15.3.443
- Author:
Jin A LEE
1
;
Bock Gie JUNG
;
Myunghwan JUNG
;
Tae Hoon KIM
;
Han Sang YOO
;
Bong Joo LEE
Author Information
1. Department of Veterinary Infectious Disease, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Korea. bjlee@chonnam.ac.kr
- Publication Type:Brief Communication ; Research Support, Non-U.S. Gov't
- Keywords:
adjuvant-like effect;
foot-and-mouth disease virus;
germanium biotite
- MeSH:
Adjuvants, Immunologic/therapeutic use;
Aluminum Silicates/*therapeutic use;
Animals;
Antibodies, Viral/*immunology;
Antibody Formation/drug effects;
*Dietary Supplements;
Ferrous Compounds/*therapeutic use;
Foot-and-Mouth Disease/*immunology/prevention & control;
Foot-and-Mouth Disease Virus/immunology;
Germanium/*therapeutic use;
Swine;
Swine Diseases/immunology/prevention & control/*virology
- From:Journal of Veterinary Science
2014;15(3):443-447
- CountryRepublic of Korea
- Language:English
-
Abstract:
We evaluated the potential ability of germanium biotite (GB) to stimulate the production of antibodies specific for foot-and-mouth disease virus (FMDV). To this aim, we measured the total FMDV-specific antibody responses and IgM production after vaccination against FMD both experimentally and in the field. GB supplementation with FMDV vaccination stimulated the production of anti-FMDV antibodies, and effectively increased IFN-gamma and TNF-alpha levels. These results suggest that GB may be a novel alternative feed supplement that can serve as a boosting agent and an immunostimulator for increasing the efficacy of FMDV vaccination in pigs.
