Histopathological and immunohistochemical findings of primary and metastatic medullary thyroid carcinoma in a young dog.
10.4142/jvs.2014.15.3.449
- Author:
Pablo PINEYRO
1
;
Miranda D VIESON
;
Jose A RAMOS-VARA
;
Martha MOON-LARSON
;
Geoffrey SAUNDERS
Author Information
1. Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA. pablop@vt.edu
- Publication Type:Case Reports
- Keywords:
calcitonin;
histopathology;
immunohistochemistry;
medullary thyroid carcinoma
- MeSH:
Animals;
Carcinoma, Neuroendocrine/pathology/radiography/*veterinary;
Dog Diseases/*pathology/radiography;
Dogs;
Female;
Laryngeal Neoplasms/secondary/veterinary;
Lung Neoplasms/secondary/veterinary;
Neoplasm Metastasis;
Thyroid Neoplasms/pathology/radiography/*veterinary
- From:Journal of Veterinary Science
2014;15(3):449-453
- CountryRepublic of Korea
- Language:English
-
Abstract:
This report describes the gross, histological, and immunohistochemical features of medullary thyroid carcinoma (MTC) with pulmonary metastases in a young dog. Sheets of pleomorphic cells supported by fibrous stroma characterized the primary mass, while metastatic nodules had a neuroendocrine pattern. Despite differing histologic features, all masses showed marked immunoreactivity against calcitonin and multiple neuroendocrine markers consistent with MTC. Although MTC is a well-recognized entity, it may be difficult to distinguish this mass from other thyroid neoplasms, necessitating immunohistochemical characterization.
