Takayasu's arteritis (TAK) is a chronic large vessel vasculitis that involves the aorta and its primary branch arteries, which can result in limb ischemia and organ damage. A clinical practice guideline has been newly developed under the leadership of the National Clinical Medical Research Center for Dermatologic and Immunologic Diseases. This guideline provides evidence-based recommendations on 11 key issues in the management of TAK, covering the diagnosis, clinical evaluation, medical treatment, antithrombotic therapy, surgical intervention as well as pregnancy, and aims to guide the diagnosis and treatment of TAK in clinical practice and improve the outcomes of patients in China. This article interprets the key points of this guideline, in order to promote its application.