Reversibility of Ultrastructural Changes of Cultured Human Nasal Epithelial Cells Induced by Tumor Necrosis Factor-alpha.
- Author:
Kyung Su KIM
1
;
Jeung Gweon LEE
;
Sung Shik KIM
;
Kuk Jin PARK
;
Joo Heon YOON
Author Information
1. Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Ultrastructure;
Reversibility;
TNF-alpha
- MeSH:
Cilia;
Epithelial Cells*;
Humans*;
Tumor Necrosis Factor-alpha*
- From:Journal of Rhinology
1997;4(1):50-56
- CountryRepublic of Korea
- Language:English
-
Abstract:
Tumor necrosis factor (TNF)-alphacan induce ultrastructural changes in cultured human nasal epithelial cells. The aims of this study are to determine the recovery time from the changes induced by TNF-alphaand observe whether various degrees of changes will result in a complete return to normal status. The recovery of cilia was observed on the third day after cessation of adding TNF-alphaand the normalization of secretory cell area was observed on the fifth day. The morphologic changes induced by TNF-alpha were reversible except with the concentration of 100 ng/ml. The results suggest that the ultrastructural changes induced by TNF-alpha are mostly reversible and that this reversibility corresponds with the in vivo state.
