Successful Treatment of A Patient with Chronic Myeloid Leukemia Complicated by Cerebral Hemorrhage Manifesting as Platelet Abnormal Elevation
10.12290/xhyxzz.2023-0377
- VernacularTitle:以血小板异常增高为表现的慢性粒细胞白血病合并脑出血患者成功救治一例
- Author:
Xin ZHANG
1
;
Xiao ZHANG
1
;
Yi GUO
1
;
Jun FENG
2
;
Zhiyuan XIAO
1
;
Zhaoxiang XIE
1
;
Jing WU
1
;
Dongrui XU
1
;
Junji WEI
1
;
Yu WANG
1
Author Information
1. Department of Neurosurgery, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
2. Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
- Publication Type:Journal Article
- Keywords:
cerebral hemorrhage;
platelet elevation;
chronic myeloid leukemia
- From:
Medical Journal of Peking Union Medical College Hospital
2024;15(1):217-222
- CountryChina
- Language:Chinese
-
Abstract:
Platelet elevation is a rare manifestation in the peripheral blood of patients with chronic myeloid leukemia (CML). In this paper, we report for the first time a case of CML combined with cerebral hemorrhage manifested by abnormally elevated platelets. The patient had elevated platelets in the peripheral blood, showed normal coagulation function, and underwent intracranial hematoma removal due to cerebral hemorrhage. After the operation, bleeding from the operated area and other systems occurred, and the patient was diagnosed as having accelerated CML after combining bone marrow biopsy and genetic testing. His condition was controlled after administration of flumatinib through a jejunal tube. Based on this patient's experience, the feasibility ofadministering flumatinib via a jejunostomy tube was determined, which is the first report of its kind in China and abroad.This article summarizes the diagnosis and treatment process of this patient, with the aim of providing a warning and reference for clinicians.
