Research Progress on Emerging Signaling Pathways Related to Muscle Bone Symbiosis
10.12290/xhyxzz.2023-0277
- VernacularTitle:肌骨共生相关信号通路研究进展
- Author:
Yandong LIU
1
;
Qiang DENG
2
;
Yanjun ZHANG
2
;
Zhongfeng LI
2
;
Randong PENG
2
;
Tiefeng GUO
2
;
Yurong WANG
2
;
Bo CHEN
1
Author Information
1. Gansu University of Traditional Chinese Medicine, Lanzhou 730030, China
2. Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
- Publication Type:Review
- Keywords:
myoblast;
osteogenesis;
signal pathway;
osteosarcopenia
- From:
Medical Journal of Peking Union Medical College Hospital
2024;15(1):147-152
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis is a systemic metabolic bone disease characterized by decreased bone mass, damage to bone tissue microstructure, increased bone fragility, and susceptibility to fractures, while sarcopenia is a syndrome characterized by progressive reduction in overall muscle mass and functional decline. Based on the common pathophysiological mechanism and close correlation between the two, the concept of "osteosarcopenia" has gradually emerged to describe the simultaneous attenuation of muscles and bones. Signaling pathways serve as important signal transmission channels between muscles and bones, and if abnormal, they can lead to osteosarcopenia. The aim of this article, therefore, is to review the signaling pathways related to osteogenesis and myogenesis, such as Hedgehog, Hippo, mTOR, MAPK, in order to provide new ideas for targeted treatment of osteosarcopenia.
