Research progress on traditional Chinese medicine in the intervention of cerebral ischemia reperfusion injury by regulating NLRP3 inflammasome
- VernacularTitle:中药调控NLRP3炎症小体干预脑缺血再灌注损伤的研究进展
- Author:
Haoge CHENG
1
,
2
;
Chenfei HE
1
,
2
;
Chunlong RAN
1
;
Chiyuan MA
1
;
Xiangzhe LIU
1
Author Information
1. Encephalopathy Center，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450099，China
2. First Clinical Medical College，Henan University of Chinese Medicine，Zhengzhou 450046，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
NLRP3 inflammasome;
cerebral ischemia reperfusion injury;
inflammation
- From:
China Pharmacy
2025;36(2):245-250
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral ischemia reperfusion injury （CIRI） is a secondary brain injury that may occur in patients with ischemic stroke during the process of blood flow recovery. NOD-like receptor protein 3 （NLRP3） inflammasome plays an important role in the occurrence and development of CIRI. Regulating the activity of NLRP3 inflammasome can induce cell pyroptosis， induce neuroinflammatory response， promote macrophage/microglial polarization， destroy the blood-brain barrier， affect angiogenesis and neurogenesis， thereby affecting CIRI. Traditional Chinese medicine has obvious advantages in the treatment of CIRI. In this paper， with NLRP3 inflammasome as the core， we systematically elucidated the mechanism of action of traditional Chinese medicines on CIRI， and found that traditional Chinese medicines monomers （such as baicalin， polygalasaponin F） and traditional Chinese medicines compound formulas （such as Huangqi guizhi wuwu decoction， Yiqi shengqing formulation） can inhibit NLRP3 inflammasome activity， reduce inflammatory response and oxidative stress， and improve neuronal injury， thereby reducing CIRI.
