Meta-analysis of the effects of gene polymorphism on plasma concentration of voriconazole in patients with invasive fungal infection
- VernacularTitle:基因多态性对侵袭性真菌感染患者伏立康唑血药浓度影响的Meta分析
- Author:
Yaxuan LI
1
;
Xingde LI
1
;
Guohui WANG
1
;
Panpan MAO
1
;
Xuejiao MA
1
;
Cangsang SONG
1
Author Information
1. Dept. of Pharmacy,Kunming First People’s Hospital,Kunming 650224,China
- Publication Type:Journal Article
- Keywords:
voriconazole;
invasive fungal infection;
gene
- From:
China Pharmacy
2025;36(2):225-231
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the influence of gene polymorphism on plasma minimum concentration (cmin) of voriconazole (VRZ) in patients with invasive fungal infection. METHODS The Cochrane Library, Embase, PubMed, Web of Science, China Biomedical Literature Database, CNKI, VIP and Wanfang Data were searched for literature on the correlation between gene polymorphisms and cmin of VRZ from inception to April 2024. After screening the literature, extracting data, and evaluating the quality of the literature, meta-analysis was performed using R 4.3.2 software. RESULTS A total of 21 studies with 2 454 patients were included. The results of meta-analysis showed that the VRZ cmin of CYP2C19 IM and PM types was significantly higher than EM type, and the VRZ cmin of IM type was significantly lower than PM type (P<0.01). The VRZ cmin of CYP2C9 rs1057910 AA type was significantly higher than AC/CC type, and that of CYP3A5 rs776746 CC type was significantly higher than TT type (P<0.01). The VRZ cmin of POR rs10954732 GG type was significantly higher than GA and AA types, and that of POR rs1057868 CT type was significantly lower than TT type (P<0.01). The VRZ cmin of ABCB1 rs1045642 CC type was significantly higher than TT type (P<0.05). The VRZ cmin of NR1I2 rs2472677 CT type was significantly higher than TT type, and rs7643645 AA type was significantly higher than AG type (P<0.05). The VRZ cmin of ABCC2 rs717620 CC type was significantly lower than CT type and TT type, and the CT type was significantly lower than TT type (P<0.01). CONCLUSIONS Mutant alleles in CYP2C19, CYP2C9 rs1057910, CYP3A5 rs776746, POR rs10954732, ABCB1 rs1045642 and NR1I2 rs7643645 can lead to a decrease in VRZ plasma concentration, and mutant allele in ABCC2 rs717620 can lead to an increase in VRZ plasma concentration.