Research progress on the mechanism of sesquiterpenoids against hepatocellular carcinoma
- VernacularTitle:倍半萜类化合物抗肝癌作用机制研究进展
- Author:
Jingxin MAO
1
,
2
;
Xin DU
1
,
2
;
Yan LI
1
Author Information
1. Technology Industry Development Center，Chongqing Medical and Pharmaceutical College，Chongqing 401331，China
2. Chongqing Key Laboratory of Toxic Traditional Chinese Medicine Administration System，Chongqing 401331，China
- Publication Type:Journal Article
- Keywords:
sesquiterpenoids;
hepatocellular carcinoma;
pharmacological action;
mechanism
- From:
China Pharmacy
2025;36(3):379-384
- CountryChina
- Language:Chinese
-
Abstract:
As one of the most common solid organ malignant tumors in the world， hepatocellular carcinoma has climbed to the fourth place in incidence rate and the second place in mortality in China， which seriously threatens people’s health. Terpenoids are natural active substances widely present in nature， among which sesquiterpenoids are numerous. They exhibit a variety of pharmacological activities， such as anti-tumor， antibacterial， anti-inflammatory， antiviral and antioxidant activities. This article reviews the research progress on the anti-hepatocellular carcinoma mechanism of sesquiterpenes from 2015 to 2024. The results showed that 24 sesquiterpenoids for the treatment of hepatocellular carcinoma have been reported in the literature in the past 10 years， and these compounds have shown potential in treating hepatocellular carcinoma by inhibiting cancer cell proliferation， inducing apoptosis， preventing invasion and metastasis， regulating immunity， and enhancing anti-drug resistance. The mechanism of anti-hepatocellular carcinoma mainly involves three regulatory pathways: phosphatidylinositol 3-kinase/protein kinase B/ mammalian target of rapamycin signaling pathway， nuclear factor kappa-B signaling pathway， and mitochondrial pathway. In the future， it is necessary to continue to explore new anti-hepatocellular carcinoma drugs with high research value， conduct in-depth analysis on the mechanism of synergistic anti-hepatocellular cancer effects of multiple components， targets， pathways， and accelerate the development of finished products in order to be widely used in clinical practice.
