Research progress on drug delivery by ophthalmic microneedle
- VernacularTitle:眼科微针药物递送的研究进展
- Author:
Han LIU
1
;
Lanyue ZHANG
1
;
Qiang SHEN
1
;
Xiaojing PENG
1
Author Information
1. Dept. of Ophthalmology，Chongqing University Jiangjin Hospital，Chongqing 402260，China
- Publication Type:Journal Article
- Keywords:
microneedle;
drug delivery;
ophthalmic medication;
bacterial keratitis;
fungal keratitis;
glaucoma;
exudative age-
- From:
China Pharmacy
2025;36(3):367-372
- CountryChina
- Language:Chinese
-
Abstract:
The presence of physiological barriers in the eye （both external and internal） makes conventional ophthalmic medications （eye drops， ointments， gels， etc.） less bioavailable and difficult to reach the posterior segment of the eye. Although intravitreal injection can deliver drugs to the posterior segment of the eye， it has disadvantages such as infection， injury， and poor tolerance. Ophthalmic microneedle breaks through the intra- and extra-ocular barriers， enabling the drug to reach the target site accurately and to be released continuously greatly avoiding intraocular infections and injuries， and improving the bioavailability of the drug， which has obvious advantages as an ophthalmic drug delivery tool. Ophthalmic microneedle can be classified into hollow microneedle， dissolving microneedle， and coated microneedle according to the usage methods. Each type of microneedle has its own advantages and has shown satisfactory performance in the treatment of diseases such as bacterial and fungal keratitis， glaucoma， exudative age-related macular degeneration， diabetic macular edema， non-infectious uveitis， corneal neovascularization， and even choroidal melanoma.
