Prognostic correlation analysis of multiple myeloma based on HALP score of peripheral blood before chemotherapy
10.13303/j.cjbt.issn.1004-549x.2025.01.010
- VernacularTitle:基于化疗前外周血的HALP评分对多发性骨髓瘤的预后相关性分析
- Author:
Min CHEN
1
;
Liying AN
1
;
Xiaojing LIN
1
;
Pan ZHAO
1
;
Xingli ZOU
1
;
Jin WEI
1
;
Xun NI
1
Author Information
1. Department of Hematology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China
- Publication Type:Journal Article
- Keywords:
multiple myeloma;
prognosis;
hemoglobin;
lymphocyte;
albumin;
platelet
- From:
Chinese Journal of Blood Transfusion
2025;38(1):61-67
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To explore the predictive value of HALP score for prognosis in patients with multiple myeloma (MM). [Methods] A retrospective analysis was conducted on laboratory indicators and related clinical data of newly diagnosed multiple myeloma (NDMM) patients, treated at the Affiliated Hospital of North Sichuan Medical College from January 2016 to October 2023, prior to their first treatment. The HALP score was calculated, and the optimal cutoff value for HALP was determined using X-tile software. Survival analysis was performed using Kaplan-Meier curves for high HALP and low HALP groups. Univariate and multivariate analyses were conducted using the Cox regression model, and a forest plot was generated using Graphpad Prism to illustrate factors that may impact patient prognosis. The predictive ability of HALP score combined with β2-microglobulin and ECOG score for prognosis in MM patients was evaluated using receiver operating characteristic curve (ROC) analysis. [Results] A total of 203 MM patients were included, with the optimal cutoff value for HALP score being 29.15 (P<0.05). Among them, 101 patients were in the low HALP score group, and 102 patients were in the high HALP score group. The results of univariate and multivariate analysis using the Cox regression model showed that a HALP score <29.15 was an independent risk factor for progression-free survival (PFS) and overall survival (OS) (P<0.05). ROC curve analysis indicated that the combination of HALP score with β2-microglobulin and ECOG score had a higher predictive value for prognosis in MM patients compared to using HALP score alone. [Conclusion] The HALP score is closely related to the prognosis of patients with NDMM. A low HALP score indicates a poorer prognosis, while the combination of HALP score with β2-microglobulin and ECOG score provides a higher predictive value when assessed together.
