Hepatitis E virus infection among blood donors in Ningbo
10.13303/j.cjbt.issn.1004-549x.2025.01.002
- VernacularTitle:宁波地区献血者戊型肝炎病毒感染情况调查
- Author:
Mingxi PENG
1
;
Yiyu LIU
1
;
Huyan MAO
1
;
Dan LIN
1
;
Lu XIN
1
;
Ning SHU
1
;
Jianfeng HAN
2
;
Feng DING
3
Author Information
1. Ningbo Central Blood Station, Ningbo 315040, China
2. Medical Affairs Department, Sansure Biotech Inc, Changsha 410205, China
3. Institute of Life Sciences, Sansure Biotech Inc, National and local Joint Engineering Research Center for Infectious Diseases and Tumor Gene Diagnosis Technology, Changsha 410205, China
- Publication Type:Journal Article
- Keywords:
blood donors;
hepatitis E virus;
blood screening;
nucleic acid testing;
genotyping
- From:
Chinese Journal of Blood Transfusion
2025;38(1):7-12
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To investigate the infection status and characteristics of HEV among voluntary blood donors in Ningbo, and to provide a basis for improving the blood screening strategy. [Methods] A total of 12 227 blood samples from voluntary blood donors in Ningbo from June 2022 to May 2023 were tested for HEV serology, enzymology, and nucleic acid testing. Furthermore, HEV gene sequencing was performed for genotyping analysis, and donors with reactive nucleic acid testing results were followed up to confirm their infection status. [Results] The reactivity rate of HEV Ag, anti-HEV IgM and anti-HEV IgG was 0.098%, 0.899% and 29.198%, respectively. There was no difference in the reactivity of anti-HEV IgM and anti-HEV IgG between genders, donation frequencies and donation types (P>0.05). The reactivity rate increased significantly with age (P<0.05). The rate of ALT disqualification (ALT>50U/L) was significantly higher than that in non-reactive samples (P<0.05). The HEV Ag reactivity rate (0.098%) was not correlated with gender, donation frequency, donation type or age. One HEV RNA positive case was found, with a positive rate of 0.008%(1/12 227). It was confirmed to be hepatitis E virus genotype 3 by sequencing analysis. Apart from HEV Ag reactivity, all other blood safety screening items were non-reactive, suggesting this case might be in the acute infection phase. The follow-up results showed that all indicators of the donor's previous blood donation were non-reactive. [Conclusion] Pre-donation ALT detection can reduce the risk of transfusion-transmitted HEV (TT-HEV) to a certain extent, and the effective way to prevent TT-HEV is to detect HEV RNA and serology of donor blood.
