Anti-osteoporosis Effect of Isorhamnetin： A Review
10.13422/j.cnki.syfjx.20241705
- VernacularTitle:异鼠李素抗骨质疏松作用的研究进展
- Author:
Shilong MENG
1
;
Xu ZHANG
1
;
Yawei XU
1
;
Yang YU
1
;
Wei LI
1
;
Yanguang CAO
2
;
Xiaolin SHI
2
;
Wei ZHANG
3
;
Kang LIU
2
Author Information
1. The Second School of Clinical Medicine，Zhejiang Chinese Medical University，Hangzhou 310053，China
2. The Second Affiliated Hospital of Zhejiang Chinese Medical University，Hangzhou 310005，China
3. TCM Hospital Xianju of the Second Affiliated Hospital of Zhejiang Chinese Medical University，Taizhou 317300，China
- Publication Type:Journal Article
- Keywords:
isorhamnetin;
osteoporosis;
mechanism of action;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(5):347-352
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis is a common senile bone metabolism disease， clinically characterized by decreased bone mass， destruction of bone microstructure， increased bone fragility， and easy fracture. It tends to occur in the elderly and postmenopausal women， seriously threatening the quality of life and physical and mental health of the elderly. At present， the treatment of osteoporosis is mainly based on oral western medicines， such as calcium， Vitamin D， and bisphosphonates. Still， there are drawbacks such as a long medication cycle and many adverse reactions. In recent years， due to the advantages of multi-component， multi-pathway， and multi-target， some traditional Chinese medicines and effective ingredients can regulate the osteogenic and osteoclastic differentiation process in both directions and are widely used in the prevention and treatment of osteoporosis. Hippophae rhamnoides is a commonly used herbal medicine， and its fruits are rich in flavonoids， polyphenols， fatty acids， vitamins， and trace elements， which have been proven to have a good anti-osteoporosis effect. Isorhamnetin is the main effective ingredient of Hippophae rhamnoides fruits， which has many pharmacological effects such as anti-inflammation， anti-oxidative stress， anti-aging， and anti-tumor. Studies have shown that isorhamnetin can participate in the regulation of bone metabolism and has a good anti-osteoporosis effect. However， the pharmacological effects and related mechanisms of isorhamnetin against osteoporosis have not been systematically summarized. Therefore， this paper reviewed the pharmacological effects and related mechanisms of isorhamnetin against osteoporosis by referring to relevant literature to provide more basis for the development and application of isorhamnetin.
