Mechanisms of Intestinal Microecology in Hyperuricemia and Traditional Chinese Medicine Intervention：A Review
10.13422/j.cnki.syfjx.20250398
- VernacularTitle:肠道微生态在高尿酸血症中的作用机制及中医药干预研究进展
- Author:
Mingyuan FAN
1
;
Jiuzhu YUAN
1
;
Hongyan XIE
1
;
Sai ZHANG
1
;
Qiyuan YAO
1
;
Luqi HE
1
;
Qingqing FU
1
;
Hong GAO
1
Author Information
1. Hospital of Chengdu University of Traditional Chinese Medicine（TCM），Chengdu 610072，China
- Publication Type:Journal Article
- Keywords:
hyperuricemia;
traditional Chinese medicine intervention;
intestinal flora;
uric acid transporter;
uric acid metabolism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(5):329-338
- CountryChina
- Language:Chinese
-
Abstract:
In recent years， hyperuricemia （HUA） has shown a rapidly increasing incidence and tends to occur in increasingly young people， with a wide range of cardiac， renal， joint， and cancerous hazards and all-cause mortality associations. Western medicine treatment has limitations such as large liver and kidney damage， medication restriction， and easy recurrence. The intestine is the major extra-renal excretion pathway for uric acid （UA）， and the intestinal microecology can be regulated to promote UA degradation. It offers great potential to develop UA-lowering strategies that target the intestinal microecology， which are promising to provide safer and more effective therapeutic approaches. Traditional Chinese medicine （TCM） can treat HUA via multiple targets and multiple pathways from a holistic view， with low toxicity and side effects. Studies have shown that intestinal microecology is a crucial target for TCM in the treatment of HUA. However， its specific mechanism of action has not been fully elucidated. Focusing on the key role of intestinal microecology in HUA， this review explores the relationship between intestinal microecology and HUA in terms of intestinal flora， intestinal metabolites， intestinal UA transporters， and intestinal barriers. Furthermore， we summarize the research progress in TCM treatment of HUA by targeting the intestinal microecology， with the aim of providing references for the development of TCM intervention strategies for HUA and the direction of future research.
