Traditional Chinese Medicine Regulates NF-κB Signaling Pathway for Treatment of Obesity： A Review
10.13422/j.cnki.syfjx.20241243
- VernacularTitle:中医药调控NF-κB相关信号通路治疗肥胖研究进展
- Author:
Zijing WU
1
;
Jixin LI
2
;
Linjie QIU
2
;
Yan REN
2
;
Chacha ZOU
1
;
Meijie LI
1
;
Wenjie LI
2
;
Jin ZHANG
2
Author Information
1. Beijing University of Chinese Medicine， Beijing 100029， China
2. Xiyuan Hospital， China Academy of Chinese Medical Sciences， Beijing 100091， China
- Publication Type:Journal Article
- Keywords:
obesity;
nuclear factor-κB （NF-κB）;
traditional Chinese medicine;
inflammation;
signaling pathway
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(5):310-318
- CountryChina
- Language:Chinese
-
Abstract:
Obesity is a chronic low-grade inflammation and a risk factor for diseases such as diabetes， hypertension， dyslipidemia， and malignant tumors， demonstrating an increasingly grim development situation. The nuclear factor-kappa B （NF-κB） signaling pathway is a key signaling pathway involved in the immune response and inflammatory response. In obese individuals， the expression of NF-κB is overactivated， which leads to abnormal inflammatory responses in the body. Therefore， it is expected to alleviate inflammation and treat obesity by regulating the NF-κB signaling pathway， which has been proven effective by a large number of studies. The available studies on the NF-κB signaling pathway mostly focus on tumors， and there is no systematic review of the mechanism of this pathway in mediating obesity and the traditional Chinese medicine （TCM） treatment. We reviewed the research progress in the pathological and physiological processes of obesity mediated by NF-κB signaling pathway and TCM treatment， aiming to give insights into the clinical treatment of obesity with TCM and provide reference targets and research directions for exploring the biological foundations and the development of new TCM preparations.
