Mechanism and Combination Therapy of Berberine in Treatment of Nonalcoholic Fatty liver Disease：A Review
10.13422/j.cnki.syfjx.20250668
- VernacularTitle:小檗碱治疗非酒精性脂肪性肝病的作用机制及联合用药研究进展
- Author:
Xiaojie WANG
1
;
Heng ZHANG
2
;
Sutong LIU
1
;
Lihui ZHANG
1
;
Wenxia ZHAO
1
Author Information
1. The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China
2. Henan General Hospital，Zhengzhou 450003，China
- Publication Type:Review
- Keywords:
nonalcoholic fatty liver disease（NAFLD）;
berberine;
mechanism;
glycolipid metabolism;
intestinal flora;
liver fibrosis;
combination therapy
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(5):269-281
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease（NAFLD） is the most common chronic liver disease in the world. Because of its complex pathogenesis， high clinical prevalence and large population， it poses a great threat and challenge to public health in the world. Therefore， active intervention measures are needed. Currently， western medicine is effective in reducing weight， reducing liver fat content， improving glucose-lipid metabolism and insulin resistance. However， for patients with NAFLD-related fibrosis and cirrhosis， there is still a lack of sufficient histological evidence to support its benefits， and randomized controlled trials are still needed to clarify. Lifestyle intervention is an important cornerstone for the treatment of NAFLD， but there are many problems such as poor implementation and low compliance of patients， and the clinical efficacy is not ideal. Traditional Chinese medicine（TCM） has the significant advantages of multiple pathways and multiple targets. Berberine， the active ingredient of TCM， can interfere with the production of NAFLD from multiple pathways， including increasing energy consumption， weight loss， improving glucose-lipid metabolism， improving insulin resistance， anti-inflammatory， anti-oxidation， regulating intestinal flora， restoring bile acid homeostasis， anti-fibrosis and so on， which can play a positive role in the treatment of NAFLD. At the same time， it was found that the combination of BBR with Chinese and western medicines had significant advantages in promoting drug absorption， improving oral bioavailability， increasing the highest biological distribution in the liver， enhancing the overall therapeutic effect of NAFLD， and reducing adverse drug reactions， which could provide reference for clinical medication.
